Winder A F, Dodson P M, Galton D J
Trans Ophthalmol Soc U K (1962). 1980 Apr;100(Pt 1):119-22.
Hypertriglyceridaemia is an inappropriate elevation in plasma of chylomicrons, very low density lipoprotein, or both, functioning in the transport of exogenous and endogenous neutral fat respectively (lewis, 1976; Miller, 1979). The elevation may be due to rare genetically-determined defects or to a specific imbalance between triglyceride production and utilization, either secondary to or accentuated by other metabolic disturbances such as obesity or diabetes mellitus. Various surveys indicate that some degree of hypertriglyceridaemia affects more than 10 per cent of the adult population, with a male preponderance and a reduced expression during childhood (Lewis, 1976). Ophthalmological complications of hypertriglyceridaemia include eruptive and other forms of xanthomata including xanthelasmata, corneal arcus, lipaemia retinalis, effects on retinal blood flow, and lipid emboli affecting vision. The clinical features overlap those of hypercholesterolaemia and these features may lead to initial presentation and diagnosis of either disorder. Recognition of the underlying disorder is important since with treatment the incidence of major cardiovascular and other problems such as pancreatitis may be reduced, and with familial disorders other affected members may then be sought.
高甘油三酯血症是指乳糜微粒、极低密度脂蛋白或两者在血浆中的异常升高，它们分别在外源性和内源性中性脂肪的转运中起作用（刘易斯，1976年；米勒，1979年）。这种升高可能是由于罕见的基因决定的缺陷，或者是甘油三酯产生与利用之间的特定失衡，这种失衡继发于其他代谢紊乱如肥胖或糖尿病，或因这些紊乱而加剧。各种调查表明，一定程度的高甘油三酯血症影响超过10%的成年人口，男性居多，在儿童期表现较轻（刘易斯，1976年）。高甘油三酯血症的眼科并发症包括疹性及其他形式的黄瘤，包括睑黄瘤、角膜弓、视网膜脂血症、对视网膜血流的影响以及影响视力的脂质栓子。这些临床特征与高胆固醇血症的特征重叠，这些特征可能导致这两种疾病的初次就诊和诊断。认识潜在疾病很重要，因为通过治疗，主要心血管疾病和其他问题如胰腺炎的发生率可能会降低，对于家族性疾病，还可以寻找其他受影响的成员。
