一名慢性髓性白血病（CML）患者中的17号染色体短臂增加：其与17号等臂染色体[i(17q)]的鉴别

17p+ in a patient with chronic myelogenous leukemia (CML): its differentiation from an isochromosome 17,[i(17q)].

作者信息

Verma R S, Dosik H

出版信息

Cancer Genet Cytogenet. 1981 Jan;3(1):55-60. doi: 10.1016/0165-4608(81)90056-x.

Abstract

Bone marrow chromosomes are usually of such poor quality as to make it difficult to band them with QFQ or GTG techniques. Because of the possibility that many nonrandom chromosomal abnormalities are present in hematologic disorders, a more reliable banding technique is necessary. Using the RFA technique an abnormality thought to be isochromosome 17, [i(17q)] in a patient with chronic myelogenous leukemia, was revealed to be 17 p+.

摘要

骨髓染色体的质量通常很差，以至于难以用QFQ或GTG技术进行显带。由于血液系统疾病中可能存在许多非随机染色体异常，因此需要一种更可靠的显带技术。使用RFA技术，在一名慢性粒细胞白血病患者中，一种被认为是17号等臂染色体[i(17q)]的异常，被发现是17p+。