雷诺现象中的人类白细胞抗原B8

HLA-B8 in Raynaud's phenomenon.

作者信息

van der Meulen J, van der Voort-Beelen J M, D'Amaro J, The T H

机构信息

Clinical Immunology Unit, University Hospital Groningen, The Netherlands.

出版信息

Tissue Antigens. 1980 Jan;15(1):81-5. doi: 10.1111/j.1399-0039.1980.tb00889.x.

DOI:10.1111/j.1399-0039.1980.tb00889.x

PMID:12735337

Abstract

A study of the distribution of histocompatibility (HLA) antigens in patients with Raynaud's phenomenon (RP) is presented, based upon the analysis of RP patients with and without connective tissue disease (CTD). In all patients, the phenomenon preceded the other symptoms of CTD by several years. The RP patients with CTD showed a significantly increased frequency (59%) of HLA-B8 compared with the frequency (23%) of that same antigen in the Dutch population. The RP patients without CTD showed no significant difference in frequency of HLA-B8. At least 50% of the patients with RP and HLA-B8 develop a CTD versus 18% of the patients without HLA-B8. It is suggested that HLA testing in patients with isolated RP may help to distinguish the patient in whom RP is the first symptom of CTD from the patient with truly primary RP.

摘要

本文基于对伴有和不伴有结缔组织病（CTD）的雷诺现象（RP）患者的分析，呈现了一项关于组织相容性（HLA）抗原在RP患者中分布情况的研究。在所有患者中，该现象比CTD的其他症状早出现数年。与荷兰人群中该抗原23%的频率相比，伴有CTD的RP患者中HLA - B8的频率显著增加（59%）。不伴有CTD的RP患者中HLA - B8的频率无显著差异。至少50%伴有RP和HLA - B8的患者会发展为CTD，而不伴有HLA - B8的患者这一比例为18%。建议对孤立性RP患者进行HLA检测，这可能有助于区分RP是CTD首发症状的患者和真正原发性RP的患者。