血红蛋白与儿童急性淋巴细胞白血病的预后
Haemoglobin and prognosis in childhood acute lymphoblastic leukaemia.
作者信息
Hann I M, Scarffe J H, Palmer M K, Evans D I, Jones P H
出版信息
Arch Dis Child. 1981 Sep;56(9):684-6. doi: 10.1136/adc.56.9.684.
Two hundred and nine children presenting consecutively with acute lymphoblastic leukaemia to a regional paediatric oncology unit were investigated to determine the prognostic significance of various factors at diagnosis. There was a strong positive correlation between the pretreatment haemoglobin level and the percentage of bone marrow blast cells in S phase of the cell cycle as assessed by flow cytometry. Patients with T- and B-cell leukaemia had significantly higher haemoglobin levels than non-B non-T patients. In patients with total white cell counts less than 20 X 10(9)/l, aged less than 13 years, and no mediastinal mass, there was no association of haemoglobin with length of first remission. However, among those with white blood counts greater than 20 +/- 10(9)/l there was a strong positive trend towards shorter remission with higher haemoglobin levels. Children with high white blood counts at diagnosis and low haemoglobin levels may have a better prognosis than predicted by the white blood count alone.
对一家地区儿科肿瘤中心连续收治的209例急性淋巴细胞白血病患儿进行了调查，以确定诊断时各种因素的预后意义。通过流式细胞术评估，预处理时的血红蛋白水平与细胞周期S期骨髓原始细胞百分比之间存在强烈的正相关。T细胞和B细胞白血病患者的血红蛋白水平显著高于非B非T患者。在白细胞总数低于20×10⁹/L、年龄小于13岁且无纵隔肿块的患者中，血红蛋白与首次缓解期长度无关。然而，在白细胞计数大于20±10⁹/L的患者中，血红蛋白水平越高，缓解期越短的趋势越明显。诊断时白细胞计数高且血红蛋白水平低的儿童可能比仅根据白细胞计数预测的预后更好。
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