Acid phosphatase activity of the lymphocytes during polychemotherapy of lymphoproliferative diseases.

In 4 adults with malignant lymphoma and in 3 cases of acute lymphoblastic leukemia the acid phosphatase activity in lymphocytes during the consecutive cycles of polychemotherapy was examined paralelly with the estimation of the receptors for sheep erythrocytes. Depression of the enzymatic reaction was observed immediately after the onset of the cytostatic treatment, its normalization between the cycles and after the full remission was reached. A remarkable and lasting decrease of the phosphatase positive lymphocytes and a change in the expression of the enzymatic reaction was noticed in the course of L-asparaginase administration. The presented investigations are the continuation of the authors' earlier studies on the positive correlation between the rosette test with neuraminidase treated sheep erythrocytes and the acid phosphatase activity in lymphoproliferative diseases.