Studies on osteoporosis. V. Comparison of methods of evaluation of osteoporosis and study of chromosome changes induced by neutron activation.

In vivo activation analysis was compared with ashing and atomic absorption spectrophotometry for the determination of total skeletal calcium content in mice. The results were close to identical. The possible mutagenic-carcinogenic effect of repeated exposure to whole body neutron irradiation was studied by chromosome analysis. Under the conditions of these experiments, no significant chromosome changes were seen.