骨质疏松症研究。十二。咪唑喹唑啉酮对实验性骨质疏松症的影响。初步报告。
Studies on osteoporoses. XII. Effect of imidazoquinazolinones on experimental osteoporosis. A preliminary report.
作者信息
Robin J C, Ambrus J L
出版信息
J Med. 1982;13(5-6):465-72.
PMID:6963333
Abstract
In vivo neutron activation analysis was employed to determine total body calcium content in C3H/St(Ha) female mice. Ninety-nine percent of calcium is in bone and loss of calcium was used as an index of osteoporosis. Heparin (500 U/kg b.i.d.) treatment for three months resulted in significant osteoporosis. BL3459 and BL4160 (6 mg/kg i.m. q.d.) prevented this heparin induced osteoporosis. BL4160 appeared to be more effective than BL3459 in this regard but the difference was not statistically significant.
摘要
采用体内中子活化分析法测定C3H/St(Ha)雌性小鼠的全身钙含量。99%的钙存在于骨骼中，钙流失被用作骨质疏松症的指标。肝素（500 U/kg，每日两次）治疗三个月导致明显的骨质疏松症。BL3459和BL4160（6 mg/kg，肌肉注射，每日一次）可预防这种肝素诱导的骨质疏松症。在这方面，BL4160似乎比BL3459更有效，但差异无统计学意义。
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