Robin J C, Ambrus J L
Res Commun Chem Pathol Pharmacol. 1982 Mar;35(3):491-8.
Neutron activation analysis was employed to determine total body calcium in C3H/St (Ha) female mice. Ninty-nine percent of total body calcium is in bone and loss of calcium was used as an index of osteoporosis. Heparin (500 U/kg B.I.D.) treatment for three months resulted in significant osteoporosis. Both human and salmon calcitonin (4 MRC U/Kg B.I.D.) prevented heparin induced osteoporosis. The results suggest that calcitonin may prevent pathological fractures in patients on anticoagulants and other osteoporosis inducing regimens.
采用中子活化分析法测定C3H/St（Ha）雌性小鼠的全身钙含量。全身钙的99%存在于骨骼中，钙流失被用作骨质疏松症的指标。肝素（500单位/千克，每日两次）治疗三个月导致显著的骨质疏松症。人降钙素和鲑鱼降钙素（4 MRC单位/千克，每日两次）均可预防肝素诱导的骨质疏松症。结果表明，降钙素可能预防接受抗凝治疗及其他导致骨质疏松症治疗方案的患者发生病理性骨折。
