Steinherz P G, Miller L P, Ghavimi F, Allen J C, Miller D R
JAMA. 1981 Dec 18;246(24):2837-9.
Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase. Headache, nausea, emesis, and lethargy were the presenting signs. The diagnosis was confirmed by arteriography. The cause is presumed to be secondary to hypercoagulability due to asparaginase-induced antithrombin III deficiency. The patients received anticoagulation therapy and recovered completely. Only two of the six reported patients without heparinization survived.
两名急性淋巴细胞白血病患儿在接受硫酸长春新碱、泼尼松和天冬酰胺酶诱导治疗期间发生硬脑膜窦血栓形成。头痛、恶心、呕吐和嗜睡为首发症状。通过动脉造影确诊。病因推测是由于天冬酰胺酶诱导的抗凝血酶III缺乏导致的高凝状态继发所致。患者接受了抗凝治疗并完全康复。报道的6例未接受肝素化治疗的患者中仅有2例存活。
