Theiss J C, Shimkin M B, Weisburger E K
J Natl Cancer Inst. 1981 Dec;67(6):1299-302.
Various sulfonic acid derivatives of 1-naphthylamine and 2-naphthylamine were tested in inbred A/St (male and female) mice by the pulmonary adenoma bioassay to determine if this class of compounds, used as intermediates in the dye-stuff industry, possesses tumorigenic activity. Neither 1-naphthylamine nor the four sulfonic acid derivatives of 1-naphthylamine tested were tumorigenic. However, 2-naphthylamine and two of the three sulfonic acid derivatives of 2-naphthylamine tested produced statistically significant lung tumor responses at comparable doses. These results indicated that this class of compounds should be examined more extensively for carcinogenic activity.
通过肺腺瘤生物测定法，在近交系A/St（雄性和雌性）小鼠中对1-萘胺和2-萘胺的各种磺酸衍生物进行了测试，以确定这类用作染料工业中间体的化合物是否具有致瘤活性。所测试的1-萘胺及其四种磺酸衍生物均无致瘤性。然而，所测试的2-萘胺及其三种磺酸衍生物中的两种在相当剂量下产生了具有统计学意义的肺肿瘤反应。这些结果表明，应对这类化合物的致癌活性进行更广泛的研究。
