生物系统中因共价修饰而产生的放大敏感性。
An amplified sensitivity arising from covalent modification in biological systems.
作者信息
Goldbeter A, Koshland D E
出版信息
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6840-4. doi: 10.1073/pnas.78.11.6840.
Abstract
The transient and steady-state behavior of a reversible covalent modification system is examined. When the modifying enzymes operate outside the region of first-order kinetics, small percentage changes in the concentration of the effector controlling either of the modifying enzymes can give much larger percentage changes in the amount of modified protein. This amplification of the response to a stimulus can provide additional sensitivity in biological control, equivalent to that of allosteric proteins with high Hill coefficients.
摘要
研究了可逆共价修饰系统的瞬态和稳态行为。当修饰酶在一级动力学区域之外起作用时，控制任何一种修饰酶的效应物浓度的小百分比变化，可导致修饰蛋白量的更大百分比变化。这种对刺激的反应放大可在生物控制中提供额外的敏感性，等同于具有高希尔系数的别构蛋白。
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