人类各种类型白血病中抗体依赖性细胞毒性降低。

Decreased antibody-dependent cellular cytotoxicity in various types of leukaemia in man.

作者信息

Jakóbisiak M, Janowska-Wieczorek A, Dobaczewska H, Kańtoch M, Marczak M, Oblakowski P, Lasek W, Sosnowska M

出版信息

Scand J Haematol. 1981 Sep;27(3):181-5. doi: 10.1111/j.1600-0609.1981.tb00470.x.

DOI:10.1111/j.1600-0609.1981.tb00470.x

Abstract

Antibody-dependent cellular cytotoxicity (ADCC) by cells from peripheral blood was studied in patients with; chronic lymphocytic leukaemia (CLL), chronic granulocytic leukaemia (CGL), acute lymphoblastic leukaemia (ALL), acute non-lymphoid leukaemia (ANLL) and compared with that of healthy donors. The ADCC activity in all the types of leukaemia was on the average lower as compared with the control values, being especially low in both CLL and CGL. Further, it has also been shown that the ADCC activity of non-leukaemic blood cells in ANLL was lower as compared with control values. The latter observation indicates that, at least in ANLL, the reduced ADCC potential of peripheral blood cells is not due to dilution of effector cells by poorly- or non-active leukaemic cells.

摘要

对慢性淋巴细胞白血病（CLL）、慢性粒细胞白血病（CGL）、急性淋巴细胞白血病（ALL）、急性非淋巴细胞白血病（ANLL）患者外周血来源细胞的抗体依赖性细胞毒性（ADCC）进行了研究，并与健康供体进行了比较。与对照值相比，所有类型白血病的ADCC活性平均较低，在CLL和CGL中尤其低。此外，还表明ANLL中非白血病血细胞的ADCC活性与对照值相比更低。后一观察结果表明，至少在ANLL中，外周血细胞ADCC潜力降低并非由于低活性或无活性白血病细胞对效应细胞的稀释所致。