Gupta S, Fernandes G
Scand J Immunol. 1982 Dec;16(6):477-80. doi: 10.1111/j.1365-3083.1982.tb00748.x.
Bone marrow T leukaemic blasts from four patients with T-cell acute lymphoblastic leukaemia (ALL) were examined as effectors in natural killing (NK) and antibody-dependent cytotoxicity (ADCC). T leukaemic blasts demonstrated both Nk (against K-562 cells as targets) and ADCC (against chicken erythrocytes (CRBC) and cells of SB cell line as targets). NK activity and ADCC (against SB cells) were comparable to NK and ADCC (against SB cells) of peripheral blood T cells from healthy controls. ADCC against CRBC by leukaemic blasts was lower than that of peripheral T cells from normal controls. Of leukaemic blasts 20-42% possessed IgG Fc receptors. This study demonstrates that T leukaemic blasts are effectors in NK and ADCC assays.
对4例T细胞急性淋巴细胞白血病（ALL）患者的骨髓T白血病原始细胞作为自然杀伤（NK）和抗体依赖性细胞毒性（ADCC）的效应细胞进行了检测。T白血病原始细胞表现出NK活性（以K-562细胞为靶标）和ADCC活性（以鸡红细胞（CRBC）和SB细胞系细胞为靶标）。NK活性和ADCC活性（针对SB细胞）与健康对照外周血T细胞的NK活性和ADCC活性（针对SB细胞）相当。白血病原始细胞针对CRBC的ADCC活性低于正常对照的外周T细胞。20% - 42%的白血病原始细胞具有IgG Fc受体。本研究表明，T白血病原始细胞在NK和ADCC检测中是效应细胞。
