Morrison A S, Buring J E, Verhoek W G, Aoki K, Leck I, Ohno Y, Obata K
J Natl Cancer Inst. 1982 Jan;68(1):91-4.
The relation of coffee drinking to the incidence rate of cancer of the lower urinary tract ("bladder cancer") was evaluated. Broadly based series of cases and series of controls drawn from the general population of each area were assembled and interviewed in Boston, Massachusetts (587 cases, 528 controls), Manchester, England (541 cases, 725 controls), and Nagoya, Japan (289 cases, 586 controls). Compared to drinkers of an average of less than 1 cup of coffee per day, those who drank more had a relative risk of bladder cancer estimated as 1.0 (0.8-1.2, 95% confidence interval). With adjustment for cigarette smoking habits, only small and irregular changes in risk were seen with increasing frequency of coffee consumption. Duration of coffee drinking showed little relation to risk of bladder cancer may be due to incomplete control of the effect of cigarette smoking. If there is a true association of coffee drinking and bladder cancer it is likely to be weak.
对饮用咖啡与下尿路癌症（“膀胱癌”）发病率之间的关系进行了评估。在马萨诸塞州波士顿（587例病例，528例对照）、英国曼彻斯特（541例病例，725例对照）和日本名古屋（289例病例，586例对照）收集并访谈了来自每个地区普通人群的广泛病例系列和对照系列。与平均每天饮用咖啡少于1杯的人相比，饮用较多咖啡的人患膀胱癌的相对风险估计为1.0（0.8 - 1.2，95%置信区间）。在对吸烟习惯进行调整后，随着咖啡饮用频率的增加，仅观察到风险有小的且不规则的变化。咖啡饮用持续时间与膀胱癌风险的关系不大，这可能是由于对吸烟影响的控制不完全。如果咖啡饮用与膀胱癌之间确实存在关联，那么这种关联可能很微弱。
