Jacobsen B K, Bjelke E, Kvåle G, Heuch I
J Natl Cancer Inst. 1986 May;76(5):823-31.
Relationships between coffee consumption and occurrence of cancer as well as mortality were explored in a Norwegian study of 13,664 men and 2,891 women who in 1967-69 reported their coffee consumption. No statistically significant positive associations were found between coffee consumption and disease. A weak negative association was found with total cancer incidence even when the first 4 of the 11 1/2 years of follow-up were excluded, and strong negative associations with coffee drinking were noted for cancer of the kidney and nonmelanoma skin cancer. For cancer of the pancreas and bladder, no increase in incidence was found among those with a high coffee consumption. In subjects less than 65 years of age at start of follow-up, coffee drinking showed a significant inverse association with colon cancer.
在挪威一项针对13664名男性和2891名女性的研究中,探讨了咖啡摄入量与癌症发生率以及死亡率之间的关系。这些男性和女性在1967年至1969年期间报告了他们的咖啡摄入量。未发现咖啡摄入量与疾病之间存在统计学上显著的正相关。即使排除随访11.5年中的前4年,仍发现咖啡摄入量与总癌症发病率之间存在微弱的负相关,并且注意到肾癌和非黑色素瘤皮肤癌与咖啡饮用之间存在强烈的负相关。对于胰腺癌和膀胱癌,咖啡摄入量高的人群中未发现发病率增加。在随访开始时年龄小于65岁的受试者中,咖啡饮用与结肠癌呈显著负相关。