Isogai Y, Mochzuki K, Maeda T
Scand J Clin Lab Invest Suppl. 1981;156:171-3. doi: 10.3109/00365518109097453.
A negative pressure red cell filteration technique using polycarbonate sieve (Nuclepore) was devised for the observation of red cell filterability (RCF) in diabetes. A significant increase of HbA1 was suggested to be closely correlated to the decrease of RCF. A greater decrease of RCF was observed in diabetics with advanced retinopathy. The increased 2,3-DPG of red cells has been observed in diabetes, but P50 changed much less than might be expected. Improved RCF was observed when Pentoxifylline was added into red cell suspensions. This suggests that Pentoxifylline will have a good effect on microcirculation where impared circulation is observed.
设计了一种使用聚碳酸酯筛（核孔滤膜）的负压红细胞过滤技术，用于观察糖尿病患者的红细胞滤过率（RCF）。研究表明，糖化血红蛋白A1（HbA1）的显著升高与RCF的降低密切相关。在患有晚期视网膜病变的糖尿病患者中，观察到RCF有更大幅度的下降。糖尿病患者红细胞中的2,3-二磷酸甘油酸（2,3-DPG）有所增加，但P50的变化比预期的要小得多。当将己酮可可碱加入红细胞悬液中时，观察到RCF有所改善。这表明己酮可可碱对观察到循环受损的微循环将有良好效果。
