Le Devehat C, Lemoine A, Cirette B, Ramet M
Scand J Clin Lab Invest Suppl. 1981;156:155-8. doi: 10.3109/00365518109097450.
In twenty control subjects, twenty diabetic patients without macro-angiopathy and forty diabetic patients with an acute and severe arteriopathy of lower limbs, we studied the red cell filterability (TFE) on total blood, the 2-3 diphosphoglycerate level (2-3 DPG) and the Adenosine Triphosphate level (ATP). The diabetic's impairement of the red cell filterability and ATP level are all the more important than the subject is suffering from an acute arteriopathy of lower limbs. For the same subjects, we notice that the 2-3 DPG level increases significantly. The filterability is related to the ATP red cell concentration. An ATP depletion produces an increase membrane rigidity and a minor filterability. These findings strongly suggest a relation that can exist between the red cell metabolic state and filterability in diabetic population with or without macroangiopathy.
在20名对照受试者、20名无大血管病变的糖尿病患者和40名患有急性严重下肢动脉病变的糖尿病患者中，我们研究了全血的红细胞滤过率（TFE）、2,3-二磷酸甘油酸水平（2,3-DPG）和三磷酸腺苷水平（ATP）。糖尿病患者红细胞滤过率和ATP水平的损害比患有急性下肢动脉病变的受试者更为严重。对于相同的受试者，我们注意到2,3-DPG水平显著升高。滤过率与红细胞ATP浓度相关。ATP耗竭会导致膜刚性增加和滤过率降低。这些发现强烈表明，在有或无大血管病变的糖尿病患者中，红细胞代谢状态与滤过率之间可能存在关联。
