各类肌炎中的HLA - D相关（DR）抗原

HLA-D related (DR) antigens in various kinds of myositis.

作者信息

Hirsch T J, Enlow R W, Bias W B, Arnett F C

出版信息

Hum Immunol. 1981 Oct;3(2):181-6. doi: 10.1016/0198-8859(81)90055-0.

Abstract

Forty-eight patients with various kinds of myositis were studied for HLA-A, B, C, and DR antigens and compared to both local and 7th International Workshop controls. No A, B, or C antigens were increased except for B8 in white patients (7/13 or 54%) (p = 0.005, pc = NS) and for B7 in black patients (6/9 or 67%) (p = 0.02, pc = NS). HLA-DR3 occurred in 8/12, or 67% of whites with polymyositis (PM) as compared to 23% of white controls (p = 0.003, pc = 0.02). HLA-DRw6 was found in 7/9, or 78%, of blacks with PM compared to 26% of black local controls (p = 0.005, pc = 0.04) and 38% of black Workshop controls (p-0.05, pc = NS). Dermatomyositis (DM) patients, however, showed no increased frequencies of any HLA antigens. HLA-DR4 was decreased overall (p = 0.005, pc = 0.04). These immunogenetic differences between PM and DM suggest that they are pathogenetically different disorders.

摘要

对48例各种类型的肌炎患者进行了HLA - A、B、C和DR抗原研究，并与本地对照组和第7届国际研讨会对照组进行了比较。除了白人患者中的B8（7/13或54%）（p = 0.005，校正p值=无显著性差异）和黑人患者中的B7（6/9或67%）（p = 0.02，校正p值=无显著性差异）外，A、B或C抗原均未增加。与23%的白人对照组相比，HLA - DR3在8/12例（即67%）的白人多发性肌炎（PM）患者中出现（p = 0.003，校正p值= 0.02）。在7/9例（即78%）的黑人PM患者中发现了HLA - DRw6，而黑人本地对照组中这一比例为26%（p = 0.005，校正p值= 0.04），在黑人研讨会对照组中为38%（p = 0.05，校正p值=无显著性差异）。然而，皮肌炎（DM）患者的任何HLA抗原频率均未增加。HLA - DR4总体上有所降低（p = 0.005，校正p值= 0.04）。PM和DM之间的这些免疫遗传学差异表明它们是病因不同的疾病。