Can Fam Physician. 1990 Mar;36:495-9.
Certain genetic markers in the major histocompatibility complex have been associated with increased risk of developing ankylosing spondylitis, rheumatoid arthritis, and systemic lupus erythematosus. These markers, however, do not appear in all patients with these diseases, suggesting that other gene products or environmental factors may play a role in disease expression. Current investigations using monoclonal antibody and peptide mapping techniques suggest that many gene products share similar protein sequences with known disease susceptibility genetic markers.
某些主要组织相容性复合体中的遗传标记与强直性脊柱炎、类风湿关节炎和系统性红斑狼疮的发病风险增加有关。然而,这些标记并不出现在所有患有这些疾病的患者中,这表明其他基因产物或环境因素可能在疾病表达中起作用。目前使用单克隆抗体和肽图谱技术的研究表明,许多基因产物与已知的疾病易感性遗传标记具有相似的蛋白质序列。