Godard P, Chantreuil J, Clauzel A M, Crastes de Paulet A, Michel F B
Respiration. 1981;42(1):43-51. doi: 10.1159/000194402.
Plasma concentrations of prostaglandins E2 (PGE2) and F2a (PGF 2a) are studied in venous and arterial blood in 14 healthy subjects and 32 asthmatic patients. In the asthmatic patients we found: (1) a good correlation between PGE2 concentration in venous blood and the seriousness of the airway obstruction; (2) a good correlation between PGE2 and PGF2a in the arterial blood, but not in the venous blood; (3) a decrease in the arterial concentrations of PGE2 and PGF2a after fenoterol-induced bronchodilatation, but the variations of PGE2 and PGF2a still correlate. None of these results were obtained in normal subjects. It seems that the asthmatic allergic patient has a disorder of the metabolism of prostaglandins in the lungs; however, the results obtained do not allow us to say if it is a causal condition or a metabolic consequence of the bronchospasm. Concerning the venous blood, there could be an increase in the peripheral production of PGE2 which might result from the hypoxemia following airway obstruction.
在14名健康受试者和32名哮喘患者中，研究了静脉血和动脉血中前列腺素E2（PGE2）和F2α（PGF2α）的血浆浓度。在哮喘患者中，我们发现：（1）静脉血中PGE2浓度与气道阻塞严重程度之间存在良好相关性；（2）动脉血中PGE2和PGF2α之间存在良好相关性，但静脉血中不存在；（3）非诺特罗诱导支气管扩张后，动脉血中PGE2和PGF2α浓度降低，但PGE2和PGF2α的变化仍具有相关性。正常受试者未获得这些结果。似乎哮喘过敏患者肺部前列腺素代谢存在紊乱；然而，所获得的结果无法让我们判断这是支气管痉挛的因果关系还是代谢后果。关于静脉血，气道阻塞后低氧血症可能导致PGE2外周生成增加。
