Igarai T, Nishimura Y, Obara K, Ono S
Tohoku J Exp Med. 1978 Jul;125(3):287-301. doi: 10.1620/tjem.125.287.
To elucidate the role of vitamin B12 in the formation of anemia in patients with rheumatoid arthritis serum B12 levels were investigated in patients with rheumatoid arthritis, patients with osteoarthritis and normal subject. Serum B12 level in patients with rheumatoid arthritis was significantly higher than that in patients with osteoarthritis and normal subjects. Serum B12 level increased in proportion to Steinbrocker's stages, and was related more closely to hemoglobin concentration than to erythrocyte count and had a high correlation with alpha1- and alpha2-globulin.
为阐明维生素B12在类风湿性关节炎患者贫血形成中的作用，对类风湿性关节炎患者、骨关节炎患者及正常受试者的血清B12水平进行了研究。类风湿性关节炎患者的血清B12水平显著高于骨关节炎患者和正常受试者。血清B12水平与斯坦布鲁克分期成比例增加，与血红蛋白浓度的关系比与红细胞计数的关系更密切，且与α1和α2球蛋白高度相关。
