Hanson R F, Williams G C
Steroids. 1978 Jun;31(6):809-13. doi: 10.1016/s0039-128x(78)80045-2.
To determine if the conversion of the intermediate, 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid (THCA), into cholic acid is influenced by taurocholate, two rats were infused intravenously with [3H] THCA until they reached a steady state. Taurocholate was then added and infused at a rate of 1 mumole/min/rat for 48 hours. The percentage of [3H] THCA recovered in the bile did not increase indicating that taurocholate does not suppress the conversion of THCA into cholic acid.
为了确定中间体3α,7α,12α-三羟基-5β-胆甾烷-26-酸（THCA）向胆酸的转化是否受牛磺胆酸盐影响，给两只大鼠静脉注射[3H]THCA直至达到稳态。然后加入牛磺胆酸盐并以1微摩尔/分钟/大鼠的速率输注48小时。胆汁中回收的[3H]THCA的百分比没有增加，表明牛磺胆酸盐不会抑制THCA向胆酸的转化。
