• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The metabolism of 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid into cholic: an enzyme assay using homogenates of human liver.

作者信息

Hanson R F, Sharp H L, Williams G C

出版信息

J Lipid Res. 1976 May;17(3):294-7.

PMID:6604
Abstract

An enzyme assay was developed to measure the conversion of the bile acid precursor, 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid (THCA), into cholic acid using homogenates of human liver biopsies. The average rate of metabolism of THCA into cholic acid was found to be 3.9 +/- 0.5 (+/- 1 SD) pmoles of cholic acid formed/mg liver/minute in twelve normal liver biopsies. This assay system can be used to determine if the syndrome of neonatal cholestasis associated with a metabolic block in the conversion of THCA into cholic acid is transmitted as a genetic trait.

摘要

相似文献

1
The metabolism of 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid into cholic: an enzyme assay using homogenates of human liver.
J Lipid Res. 1976 May;17(3):294-7.
2
The metabolism of 3alpha, 7alpha, 12alpha-trihydorxy-5beta-cholestan-26-oic acid in two siblings with cholestasis due to intrahepatic bile duct anomalies. An apparent inborn error of cholic acid synthesis.两名因肝内胆管异常导致胆汁淤积的同胞中3α, 7α, 12α-三羟基-5β-胆甾烷-26-酸的代谢。一种明显的胆酸合成先天性缺陷。
J Clin Invest. 1975 Sep;56(3):577-87. doi: 10.1172/JCI108127.
3
Effect of taurocholate on the conversion of 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid into cholic acid.牛磺胆酸盐对3α,7α,12α-三羟基-5β-胆甾烷-26-酸转化为胆酸的影响。
Steroids. 1978 Jun;31(6):809-13. doi: 10.1016/s0039-128x(78)80045-2.
4
Biosynthesis of cholic acid in rat liver. 24-Hydroxylation of 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestanoic acid.大鼠肝脏中胆酸的生物合成。3α,7α,12α-三羟基-5β-胆甾烷酸的24-羟基化作用。
J Biol Chem. 1975 Oct 25;250(20):8243-7.
5
Synthesis of coenzyme A esters of 3alpha,7alpha,12alpha-trihydroxy- and 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oic acids for the study of beta-oxidation in bile acid biosynthesis.合成3α,7α,12α-三羟基-和3α,7α-二羟基-24-氧代-5β-胆甾烷-26-酸的辅酶A酯用于胆汁酸生物合成中β-氧化的研究。
Steroids. 2001 Jun;66(6):499-504. doi: 10.1016/s0039-128x(00)00209-9.
6
Effect of the side-chain structure on the specificity of beta-oxidation in bile acid biosynthesis in rat liver homogenates.侧链结构对大鼠肝脏匀浆中胆汁酸生物合成中β-氧化特异性的影响。
J Lipid Res. 1997 Dec;38(12):2589-602.
7
Metabolism of 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid in normal subjects with an intact enterohepatic circulation.3α,7α,12α-三羟基-5β-胆甾烷-26-酸在肠肝循环完整的正常受试者中的代谢
J Lipid Res. 1977 Sep;18(5):656-9.
8
Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid.鸊鷉科鸟类中的胆汁酸：牛磺酸结合的（24R,25R）-3α,7α,24-三羟基-5β-胆甾烷-27-酸和 3α,7α-二羟基-5β-胆甾烷-27-酸的两个差向异构体（25R 和 25S）。
Steroids. 2011 Sep-Oct;76(10-11):1126-35. doi: 10.1016/j.steroids.2011.04.017. Epub 2011 May 11.
9
The catabolism of cholesterol in vitro. Formation of 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoic acid from cholesterol by rat liver.胆固醇在体外的分解代谢。大鼠肝脏将胆固醇转化为3-α,7-α,12-α-三羟基-5-β-胆甾烷酸。
Biochem J. 1969 Aug;114(1):1-3. doi: 10.1042/bj1140001.
10
Cholic acid biosynthesis: the enzymatic defect in cerebrotendinous xanthomatosis.胆酸生物合成：脑腱黄瘤病中的酶缺陷
J Clin Invest. 1979 Jan;63(1):38-44. doi: 10.1172/JCI109275.

引用本文的文献

1
Biosynthesis of cholic acid in rat liver: formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy- and 3 alpha, 7 alpha, 12 alpha, 24-tetrahydroxy-5 beta-cholestanoic acids.大鼠肝脏中胆酸的生物合成：由3α,7α,12α-三羟基-和3α,7α,12α,24-四羟基-5β-胆甾烷酸形成胆酸。
Lipids. 1980 Feb;15(2):113-21. doi: 10.1007/BF02533886.
2
Familial intrahepatic cholestasis: an update.家族性肝内胆汁淤积症：最新进展
Yale J Biol Med. 1979 Jan-Feb;52(1):89-98.