Hanson R F, Williams G C
J Lipid Res. 1977 Sep;18(5):656-9.
The formation of cholic acid from 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid (THCA) was studied in two normal subjects. [3H]THCA and [14C]cholic acid were administered intravenously by simultaneous injection and the specific activities (percent injected amount/mumol) of [3H]- and [14C]cholic acid were measured in bile samples collected over a 5-day period. If the administered [3H]-THCA is rapidly and completely metabolized into cholic acid, the areas under the specific activity curves of [3H]- and [14C]cholic acid should be identical. In these two subjects, the area under the [3H]cholic acid specific activity decay curves was only 18.4% and 9.0% less than the area under the [14C]cholic acid specific activity decay curves. Thus, there is rapid and nearly complete metabolism of intravenously administered [3H]THCA into cholic acid.
在两名正常受试者中研究了由3α,7α,12α-三羟基-5β-胆甾烷-26-酸（THCA）形成胆酸的过程。通过同时注射静脉给予[3H]THCA和[14C]胆酸，并在5天内收集的胆汁样本中测量[3H]-和[14C]胆酸的比活性（注射量百分比/μmol）。如果给予的[3H]-THCA迅速且完全代谢为胆酸，[3H]-和[14C]胆酸比活性曲线下的面积应该相同。在这两名受试者中，[3H]胆酸比活性衰减曲线下的面积仅比[14C]胆酸比活性衰减曲线下的面积分别少18.4%和9.0%。因此，静脉给予的[3H]THCA能迅速且几乎完全代谢为胆酸。
