• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

黑色素瘤细胞上的DR抗原:单克隆抗体分析

DR antigens on melanoma cells: analysis with monoclonal antibodies.

作者信息

Mitchell K F, Ward F E, Koprowski H

出版信息

Hum Immunol. 1982 Feb;4(1):15-26. doi: 10.1016/0198-8859(82)90046-5.

DOI:10.1016/0198-8859(82)90046-5
PMID:6949895
Abstract

Two monoclonal antibodies (691-13-17 and 37-7) can precipitate DR antigens from radioiodinated, detergent solubilized melanoma cells. However, after complete depletion of lysates with one antibody (691-13-17) alpha-like chains can be still be precipitated from some melanoma cells by the other antibody (37-7). Antibody 37-7 also precipitates an additional distinct antigen from SK-MEL 37 but not from any five other melanoma cell lines.

摘要

两种单克隆抗体(691-13-17和37-7)能够从经放射性碘化、去污剂溶解的黑色素瘤细胞中沉淀出DR抗原。然而,在用一种抗体(691-13-17)将裂解物完全耗尽后,另一种抗体(37-7)仍可从一些黑色素瘤细胞中沉淀出α样链。抗体37-7还能从SK-MEL 37中沉淀出另一种独特的抗原,但从其他五种黑色素瘤细胞系中则不能。

相似文献

1
DR antigens on melanoma cells: analysis with monoclonal antibodies.黑色素瘤细胞上的DR抗原:单克隆抗体分析
Hum Immunol. 1982 Feb;4(1):15-26. doi: 10.1016/0198-8859(82)90046-5.
2
HLA-DR antigens of autologous melanoma and B lymphoblastoid cell lines: differences in glycosylation but not protein structure.自体黑色素瘤和B淋巴母细胞系的HLA-DR抗原:糖基化存在差异但蛋白质结构无差异。
J Immunol. 1984 Jul;133(1):315-20.
3
Two-dimensional gel analysis of a second family of class II molecules by polymorphic HLA-DR4,5, and w9 monoclonal antibodies.利用多态性HLA-DR4、5和w9单克隆抗体对第二类分子的第二个家族进行二维凝胶分析。
J Immunol. 1984 May;132(5):2478-84.
4
Analysis of the biosynthesis of HLA-DR glycoproteins in human malignant melanoma cell lines.人恶性黑色素瘤细胞系中HLA - DR糖蛋白生物合成的分析
J Immunol. 1981 Jun;126(6):2408-13.
5
Direct demonstration of an HLA-DR allotypic determinant on the low molecular weight (beta) subunit using a mouse monoclonal antibody specific for DR3.使用对DR3特异的小鼠单克隆抗体直接证实低分子量(β)亚基上的HLA - DR同种异型决定簇。
J Exp Med. 1982 Jul 1;156(1):104-11. doi: 10.1084/jem.156.1.104.
6
Workshop on monoclonal antibodies to human melanoma-associated antigens: findings of the Seattle group.人类黑色素瘤相关抗原单克隆抗体研讨会:西雅图小组的研究结果
Hybridoma. 1982;1(4):399-402. doi: 10.1089/hyb.1.1982.1.399.
7
Characterization of a monoclonal antibody recognizing a monomorphic determinant of the alpha chain of class II DQ antigens.
Scand J Immunol. 1986 Sep;24(3):313-9. doi: 10.1111/j.1365-3083.1986.tb02099.x.
8
Identification of three class II antigens, DR7, MB2, and MT3, from a homozygous human cell line.从一个纯合子人类细胞系中鉴定出三种II类抗原,即DR7、MB2和MT3。
Hum Immunol. 1984 Mar;9(3):159-74. doi: 10.1016/0198-8859(84)90043-0.
9
Recombinant interferon-gamma can induce the expression of HLA-DR and -DC on DR-negative melanoma cells and enhance the expression of HLA-ABC and tumor-associated antigens.重组干扰素-γ可诱导DR阴性黑色素瘤细胞上HLA-DR和-DC的表达,并增强HLA-ABC和肿瘤相关抗原的表达。
Eur J Immunol. 1985 Feb;15(2):118-23. doi: 10.1002/eji.1830150204.
10
The expression of tumor-associated antigens in primary and metastatic human malignant melanoma.肿瘤相关抗原在原发性和转移性人类恶性黑色素瘤中的表达
Behring Inst Mitt. 1984 May(74):19-23.

引用本文的文献

1
HLA-DR histocompatibility leukocyte antigens permit cultured human melanoma cells from early but not advanced disease to stimulate autologous lymphocytes.HLA - DR组织相容性白细胞抗原使来自早期而非晚期疾病的培养人黑色素瘤细胞能够刺激自体淋巴细胞。
J Clin Invest. 1984 Jan;73(1):267-71. doi: 10.1172/JCI111201.
2
IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells.IgG2a单克隆抗体通过与效应细胞相互作用抑制人类肿瘤生长。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4761-5. doi: 10.1073/pnas.79.15.4761.
3
The Gordon Wilson lecture. Monoclonal antibodies in human cancer.
戈登·威尔逊讲座。人类癌症中的单克隆抗体。
Trans Am Clin Climatol Assoc. 1985;96:81-97.
4
Differentiation and activation phenotypes of lung T lymphocytes differ from those of circulating T lymphocytes.肺T淋巴细胞的分化和激活表型与循环T淋巴细胞不同。
J Clin Invest. 1985 Jul;76(1):60-5. doi: 10.1172/JCI111977.
5
Characterization of Lewis antigens in normal colon and gastrointestinal adenocarcinomas.正常结肠和胃肠道腺癌中Lewis抗原的特征分析
Proc Natl Acad Sci U S A. 1985 Jun;82(11):3552-6. doi: 10.1073/pnas.82.11.3552.