黑色素瘤细胞上的DR抗原：单克隆抗体分析
DR antigens on melanoma cells: analysis with monoclonal antibodies.
作者信息
Mitchell K F, Ward F E, Koprowski H
出版信息
Hum Immunol. 1982 Feb;4(1):15-26. doi: 10.1016/0198-8859(82)90046-5.
PMID:6949895
Abstract
Two monoclonal antibodies (691-13-17 and 37-7) can precipitate DR antigens from radioiodinated, detergent solubilized melanoma cells. However, after complete depletion of lysates with one antibody (691-13-17) alpha-like chains can be still be precipitated from some melanoma cells by the other antibody (37-7). Antibody 37-7 also precipitates an additional distinct antigen from SK-MEL 37 but not from any five other melanoma cell lines.
摘要
两种单克隆抗体（691-13-17和37-7）能够从经放射性碘化、去污剂溶解的黑色素瘤细胞中沉淀出DR抗原。然而，在用一种抗体（691-13-17）将裂解物完全耗尽后，另一种抗体（37-7）仍可从一些黑色素瘤细胞中沉淀出α样链。抗体37-7还能从SK-MEL 37中沉淀出另一种独特的抗原，但从其他五种黑色素瘤细胞系中则不能。
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