Hoeltge G A, Dyment P G, Slovak M L
Med Pediatr Oncol. 1982;10(1):53-9. doi: 10.1002/mpo.2950100109.
A three-year-old acute lymphocytic leukemia (ALL) patient had a modal chromosome count of 26 in her bone marrow metaphases. The leukemia was "common" ALL by cytochemical and immunologic studies. Five other cases had been reported previously, and all have had a near haploidy varying from 26 to 32 chromosomes. Disomy of chromosomes 18 and 21 is a consistent feature of this disease. Severe hypodiploidy correlates with microblastosis requiring morphologic separation from non-neoplastic small lymphocytes.
一名三岁的急性淋巴细胞白血病（ALL）患者骨髓中期染色体众数计数为26条。通过细胞化学和免疫学研究，该白血病为“普通”ALL。此前已报道过另外5例病例，所有病例均有接近单倍体的情况，染色体数在26条至32条之间变化。18号和21号染色体的二体性是这种疾病的一个一致特征。严重亚二倍体与原始细胞增多症相关，需要在形态学上与非肿瘤性小淋巴细胞区分开来。
