Bauchinger M, Mezger J
Institut für Strahlenbiologie, GSF, Neuherberg/München, F.R.G.
Cancer Genet Cytogenet. 1990 Aug 1;48(1):13-21. doi: 10.1016/0165-4608(90)90210-2.
Chromosome analysis in bone marrow cells of a 41-year-old woman with malignant mastocytosis (MM) revealed near-haploid (59%), near-diploid (36%), and polyploid (5%) cells. Near-haploid cells had a mode of 25 chromosomes with variable disomy and nullisomy of particular chromosomes. Disomy for chromosome 19 and chromosome 20 were most common. A 17p+ marker was observed in all cells. Other structural chromosomal changes were dicentrics, ring chromosomes, translocations, and double minutes. The modal chromosome number in near-diploid cells was 46 with a range of 41-52. The majority of cells with 46 chromosomes were pseudodiploid and only a few had a normal female karyotype. As in near-haploid cells, various structural chromosomal changes were found. The 17p+ marker was also present in occasional cells suggesting a relationship between the two tumor cell populations. Chromosome numbers in polyploid cells ranged from 70 to about 600. Identical copies of dicentrics or markers were identified in some cells.
对一名41岁恶性肥大细胞增多症（MM）女性患者的骨髓细胞进行染色体分析，发现存在近单倍体（59%）、近二倍体（36%）和多倍体（5%）细胞。近单倍体细胞的染色体众数为25条，特定染色体存在可变的二体性和缺体性。19号和20号染色体的二体性最为常见。在所有细胞中均观察到17p+标记。其他染色体结构改变包括双着丝粒、环状染色体、易位和双微体。近二倍体细胞的染色体众数为46条，范围为41 - 52条。大多数46条染色体的细胞为假二倍体，只有少数具有正常女性核型。与近单倍体细胞一样，发现了各种染色体结构改变。偶尔也有细胞存在17p+标记，提示这两种肿瘤细胞群体之间存在关联。多倍体细胞的染色体数范围为70至约600条。在一些细胞中鉴定出双着丝粒或标记的相同拷贝。
