前列腺素F2α对种马精子生成和精液特性的影响。

Influence of prostaglandin F2 alpha on sperm production and seminal characteristics of the stallion.

作者信息

Kreider J L, Ogg W L, Turner J W

出版信息

Prostaglandins. 1981 Dec;22(6):903-13. doi: 10.1016/0090-6980(81)90020-4.

Abstract

Six mature stallions were used to test the effect of prostaglandin F2 alpha (PGF2 alpha ) on sperm production and seminal characteristics. Semen was collected from each stallion twice weekly 1 hr following a 10 mg intramuscular injection of PGF2 alpha or a sham injection. A switchback design was used so that three stallions received PGF2 alpha and three served as controls during the first 9 weeks (period 1). Treatment regimens were reversed during the second 9 weeks (period 2). Treatment of stallions with PGF2 alpha resulted in an increase (P less than .05) in gel free seminal volume and a decrease in sperm cell concentration. Total spermatozoa, sperm cell motility, and percentage of primary and secondary sperm abnormalities of ejaculates were not significantly affected by treatment of stallions with PGF2 alpha before semen collection. All treated stallions exhibited a pronounced sweating response to the drug. During the experiment, two of the six stallions masturbated within 20 to 30 minutes after PGF2 alpha treatment without achieving an erection.

摘要

选用6匹成年种马，以测试前列腺素F2α（PGF2α）对精子生成和精液特性的影响。每周两次在肌肉注射10毫克PGF2α或假注射后1小时，从每匹种马采集精液。采用折返设计，使得在最初9周（第1阶段），3匹种马接受PGF2α处理，3匹作为对照。在接下来的9周（第2阶段），处理方案颠倒。用PGF2α处理种马导致无凝胶精液体积增加（P<0.05），精子细胞浓度降低。采集精液前用PGF2α处理种马，射精的总精子数、精子细胞活力以及初级和次级精子异常百分比均未受到显著影响。所有接受处理的种马对该药物均表现出明显的出汗反应。实验期间，6匹种马中有2匹在PGF2α处理后20至30分钟内自慰，但未勃起。