Shirahama T, Skinner M, Westermark P, Rubinow A, Cohen A S, Brun A, Kemper T L
Am J Pathol. 1982 Apr;107(1):41-50.
Three lesions that characterize the nosologic findings in the brain of Alzheimer's presenile dementia and senile dementia of Alzheimer type, ie, neuritic plaque, neurofibrillary tangle, and microangiopathy, all are frequently associated with amyloid deposition. There has been some question, however, as to whether these lesions share the same etiology. Moreover, the specific chemical nature of amyloid associated with these lesions has not yet been determined. In the present study, formalin-fixed paraffin sections of the affected brains were tested immunocytochemically for their reactivity against antiserum to prealbumin (recently disclosed as the major constituent of amyloid associated with familial amyloidotic polyneuropathy as well as senile cardiac amyloid) and known components of other types of amyloid (AA, AP, etc.). The results demonstrated that amyloid deposits in all three lesions reacted with anti-prealbumin, suggesting that it is a common constituent of these lesions. Indeed, it is likely that prealbumin is the major constituent of amyloid associated with neuritic plaque, neurofibrillary tangle, and microangiopathy.
阿尔茨海默病早老性痴呆及阿尔茨海默型老年性痴呆患者脑内的病理特征性病变，即神经炎性斑块、神经原纤维缠结和微血管病变，均常与淀粉样蛋白沉积相关。然而，这些病变是否具有相同的病因仍存在一些疑问。此外，与这些病变相关的淀粉样蛋白的具体化学性质尚未确定。在本研究中，对受累脑的福尔马林固定石蜡切片进行免疫细胞化学检测，以检测其对抗前白蛋白抗血清（最近发现其为与家族性淀粉样多神经病以及老年性心脏淀粉样变相关的淀粉样蛋白的主要成分）以及其他类型淀粉样蛋白（AA、AP等）已知成分的反应性。结果表明，所有三种病变中的淀粉样蛋白沉积物均与抗前白蛋白发生反应，提示其为这些病变的共同成分。事实上，前白蛋白很可能是与神经炎性斑块、神经原纤维缠结和微血管病变相关的淀粉样蛋白的主要成分。
