Torack R M, Lynch R G
Acta Neuropathol. 1981;53(3):189-96. doi: 10.1007/BF00688021.
A cytochemical study of 14 cases of adult dementia revealed the presence of gamma globulin in the amyloid of three cases of congophilic angiopathy by means of immunofluorescence microscopy. In these cases, the additional identification of human albumin is regarded to indicate a non-specific macromolecular leak in the blood-brain barrier. Both reactions are inhibited by prior absorption with the appropriate serum protein. Twelve of the 14 cases had congophilic amyloid deposits which were not affected by permanganate pre-treatment, so that immunoglobulin content remains a possibility, despite the negative immune reaction. Alcianophilia was studied at a varying pH and electrolyte concentration, but these findings do not appear to have nosologic significance. The three positive cases are characterized by a rapid terminal decline. The heterogeneity of amyloid and the significance of immunoamyloid in the pathogenesis of adult dementia is discussed.
对14例成人痴呆症患者进行的细胞化学研究显示，通过免疫荧光显微镜检查，在3例嗜刚果红血管病的淀粉样蛋白中发现了γ球蛋白。在这些病例中，人白蛋白的额外鉴定被认为表明血脑屏障存在非特异性大分子渗漏。两种反应都可被相应血清蛋白预先吸收所抑制。14例中有12例有嗜刚果红淀粉样蛋白沉积，这些沉积不受高锰酸钾预处理的影响，因此尽管免疫反应呈阴性，但免疫球蛋白含量仍有可能存在。在不同的pH值和电解质浓度下研究了阿利新蓝染色，但这些发现似乎没有疾病分类学意义。3例阳性病例的特点是病情迅速终末期恶化。本文讨论了淀粉样蛋白的异质性以及免疫淀粉样蛋白在成人痴呆症发病机制中的意义。
