正常人群中第二补体成分缺乏与HLA单倍型A10、B18的关联。
Deficiency of the second complement component association with the HLA haplotype A10, B18 in a normal population.
作者信息
Rynes R I, Britten A F, Pickering R J
出版信息
Ann Rheum Dis. 1982 Feb;41(1):93-6. doi: 10.1136/ard.41.1.93.
Abstract
Serum C2 activity was measured in 135 individuals drawn from a panel of 418 tissue-typed blood donors. The study group included all donors with HLA antigens A10 and B18. Heterozygote C2 deficiency (C2Dhet) was defined by reference to the range of C2 activity in previously studied obligate heterozygotes. Five donors were C2Dhet. Family studies confirmed that C2Dhet was associated in all instance with an A10, B18 haplotype. The minimum frequency for C2Dhet was 1.2% in the panel of 418 donors and 62.5% in those donors with an A10, B18 haplotype.
摘要
在从418名进行了组织分型的献血者组成的样本中抽取的135名个体中测量了血清C2活性。研究组包括所有具有HLA抗原A10和B18的献血者。杂合子C2缺乏症（C2Dhet）是参照先前研究的纯合子杂合子中C2活性范围来定义的。有5名献血者为C2Dhet。家系研究证实，在所有情况下C2Dhet都与A10、B18单倍型相关。在418名献血者的样本中，C2Dhet的最低频率为1.2%，而在具有A10、B18单倍型的献血者中为62.5%。
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