慢性骨髓增殖性疾病中的嗜碱性粒细胞、组胺和胃酸分泌素

Basophils, histamine and gastric acid secretin in chronic myeloproliferative disorders.

作者信息

Gray A G, Boughton B J, Burt D S, Struthers G R

出版信息

Br J Haematol. 1982 May;51(1):117-23. doi: 10.1111/j.1365-2141.1982.tb07296.x.

DOI:10.1111/j.1365-2141.1982.tb07296.x

Abstract

Fourteen patients with polycythaemia rubra vera (PRV) and four with chronic granulocytic leukaemia (CGL) were studied to examine the relationship between basophil counts, blood histamine, gastric acid secretion and dyspepsia or peptic ulceration. Basophil counts and blood histamine were markedly raised in untreated CGL but only marginally increased in other cases. Blood histamine and basophil counts were well correlated. Gastric acid secretion was normal in 10 out of 11 cases, and did not correlate with blood histamine values. The previously reported high incidence of dyspepsia and peptic ulceration is examined and its mechanisms are discussed.

摘要

对14例真性红细胞增多症（PRV）患者和4例慢性粒细胞白血病（CGL）患者进行了研究，以探讨嗜碱性粒细胞计数、血组胺、胃酸分泌与消化不良或消化性溃疡之间的关系。未经治疗的CGL患者嗜碱性粒细胞计数和血组胺显著升高，但其他病例仅略有增加。血组胺与嗜碱性粒细胞计数密切相关。11例中有10例胃酸分泌正常，且与血组胺值无关。对先前报道的消化不良和消化性溃疡的高发病率进行了研究，并讨论了其机制。