Gingold N
Onkologie. 1979 Apr;2(2):70-4. doi: 10.1159/000214474.
Since the discovery of a very high blood histamine level in chronic myelocytic leukemia (CML) 1936, the author could ascertain that this parameter is very useful in the differential diagnosis between CML and various "leukemoid" reactions; in the early diagnosis of CML and in the differential diagnosis between CML and other myeloproliferative disorders. Recent researches proved that no correlation exists between blood histamine level and basophil count in the peripheral blood. Further investigations in this field have to clear up the questions whether it is possible by means of repeated controls of the blood histamine level to predict the development of a polycythemia vera into CML or to establish in a case of osteomyelosclerosis that this disease has been Preceeded by A CML.
自1936年在慢性粒细胞白血病（CML）中发现血液组胺水平极高以来，作者可以确定该参数在CML与各种“类白血病”反应的鉴别诊断中非常有用；在CML的早期诊断以及CML与其他骨髓增殖性疾病的鉴别诊断中也很有用。最近的研究证明，外周血中血液组胺水平与嗜碱性粒细胞计数之间不存在相关性。该领域的进一步研究必须弄清楚以下问题：是否可以通过反复检测血液组胺水平来预测真性红细胞增多症发展为CML，或者在骨髓硬化症病例中确定该疾病之前是否有CML病史。
