Saeed S A, Mitchell M D
Prostaglandins Leukot Med. 1982 Mar;8(3):185-9. doi: 10.1016/0262-1746(82)90041-5.
The ability of human low-density lipoprotein (LDL) and high-density lipoprotein (HDL) to inhibit the biosynthesis of prostaglandin (PG) E2, F2 alpha prostacyclin from arachidonic acid by bull seminal vesicle (BSV) PG synthase was studied. Both LDL an HDL inhibited the PG synthase activity in BSV microsomes. The greatest inhibitory effect was observed against th biosynthesis of PGE2. These results show an higher to unrecognised property of human lipoproteins that may mediate some of the biological actions of these substances.
研究了人低密度脂蛋白（LDL）和高密度脂蛋白（HDL）抑制牛精囊（BSV）前列腺素（PG）合酶从花生四烯酸生物合成前列腺素（PG）E2、F2α前列环素的能力。LDL和HDL均抑制BSV微粒体中的PG合酶活性。观察到对PGE2生物合成的抑制作用最大。这些结果表明人脂蛋白具有一种尚未被认识的特性，这种特性可能介导了这些物质的一些生物学作用。
