Pinto D J, Sanderson P J
Br Med J. 1980 Feb 2;280(6210):275-7. doi: 10.1136/bmj.280.6210.275.
A prospective randomised trial was carried out on 263 patients admitted for appendicectomy. In those patients with normal or inflamed appendix only, wound sepsis occurred in five (5%) of the 96 patients receiving metronidazole compared with seven (7%) of the 91 controls. In patients with gangrenous or perforated appendices, however, 15 of the 32 patients (47%) receiving ampicillin and five (16%) of 31 patients receiving metronidazole developed a wound infection (p less than 0.025). Therapeutic courses of metronidazole significantly reduced wound sepsis rate in those with gangrenous or perforated appendices. Together with another antibiotic it should form part of the management of such patients, but antibiotics are unlikely to reduce further the low rate of wound infection in patients with normal or inflamed appendices.
对263例因阑尾炎入院接受阑尾切除术的患者进行了一项前瞻性随机试验。仅在阑尾正常或发炎的患者中，96例接受甲硝唑治疗的患者中有5例（5%）发生伤口感染，而91例对照组中有7例（7%）发生伤口感染。然而，在阑尾坏疽或穿孔的患者中，32例接受氨苄青霉素治疗的患者中有15例（47%）发生伤口感染，31例接受甲硝唑治疗的患者中有5例（16%）发生伤口感染（P<0.025）。甲硝唑治疗疗程显著降低了阑尾坏疽或穿孔患者的伤口感染率。与另一种抗生素联合使用时，它应成为此类患者治疗方案的一部分，但抗生素不太可能进一步降低阑尾正常或发炎患者的低伤口感染率。
