Akimoto Y, Kaneko K, Tamura T
J Oral Maxillofac Surg. 1982 May;40(5):287-93. doi: 10.1016/0278-2391(82)90220-8.
Forty-four patient who underwent enucleation of jaw cysts were administered amoxicillin preoperatively. Specimens of venous blood (44), walls and fluids from periodontal (31) and dentigerous (13) cysts, and jawbone (26) were obtained during the operation and assayed for amoxicillin content. Measurable concentrations were found in all specimens. The levels were higher in periodontal cysts than in dentigerous cysts, and higher in maxillary bone than in mandibular bone. Since amoxicillin can easily and rapidly pass through the epithelial lining according to the change in concentration, the penetration by amoxicillin of blood/cyst wall/cyst fluid probably depends on simple diffusion.
44例接受颌骨囊肿摘除术的患者在术前接受了阿莫西林治疗。术中采集了静脉血样本（44份）、牙周囊肿（31份）和含牙囊肿（13份）的囊壁及囊液样本，以及颌骨样本（26份），并检测其中的阿莫西林含量。所有样本中均检测到了可测量的浓度。牙周囊肿中的浓度高于含牙囊肿，上颌骨中的浓度高于下颌骨。由于阿莫西林可根据浓度变化轻松快速地穿过上皮衬里，阿莫西林在血液/囊壁/囊液中的渗透可能取决于简单扩散。
