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Dominance of resistance to the alkylating agent 1,2:5,6-dianhydrogalactitol in P388 mouse lymphoma hybrid cells.

作者信息

Pályi I, Bence J, Szikla K, Hullán L

机构信息

Research Institute of Oncopathology, National Institute of Oncology, Budapest, Hungary.

出版信息

Cancer Chemother Pharmacol. 1989;23(1):41-6. doi: 10.1007/BF00258456.

DOI:10.1007/BF00258456
PMID:2909289
Abstract

Cultured P388/S mouse lymphoma cells resistant to 5-bromodeoxyuridine (BUdR) and deficient in thymidine kinase (TK-) were fused with P388/DAG cells resistant to 1,2:5,6-dianhydrogalactitol (DAG), an anticancer alkylating agent, and to 6-thioguanine (6-TG) and deficient in hypoxanthine phosphoribosyl-transferase (HPRT-). Sensitivity to DAG in the hybrid line was very close to that in the P388/DAG line, which means that resistance to DAG was inherited in a quasi-dominant manner. Hybrid cells showed cross-resistance, similar to that of the DAG-resistant line, to two other hexitols, dibromodulcitol (DBD) and disuccinyldianhydrogalactitol (DisuDAG).

摘要

相似文献

1
Dominance of resistance to the alkylating agent 1,2:5,6-dianhydrogalactitol in P388 mouse lymphoma hybrid cells.
Cancer Chemother Pharmacol. 1989;23(1):41-6. doi: 10.1007/BF00258456.
2
Dominant expression of multidrug resistance in intraspecific murine lymphoma hybrid cells.多药耐药性在种内小鼠淋巴瘤杂交细胞中的显性表达。
Cancer Chemother Pharmacol. 1994;34(1):81-5. doi: 10.1007/BF00686118.
3
Development and some characteristics of a P388 leukemia strain resistant to 1, 2:5, 6-dianhydrogalactitol.对1,2:5,6-二脱水半乳糖醇耐药的P388白血病细胞株的建立及其某些特性
Eur J Cancer Clin Oncol. 1986 Jul;22(7):773-80. doi: 10.1016/0277-5379(86)90362-7.
4
[The effect of 3,4-disuccinyldianhydrogalactitol, N-nitrosourea and their combination on DNA synthesis in normal and mouse P388 tumor cells].[3,4-二琥珀酰脱水半乳糖醇、N-亚硝基脲及其联合应用对正常及小鼠P388肿瘤细胞DNA合成的影响]
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Effect of phenobarbital on the toxicity and antitumor activity of dibromodulcitol and dianhydrogalactitol.苯巴比妥对二溴卫矛醇和二去水半乳糖醇的毒性及抗肿瘤活性的影响。
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引用本文的文献

1
Dominant expression of multidrug resistance in intraspecific murine lymphoma hybrid cells.多药耐药性在种内小鼠淋巴瘤杂交细胞中的显性表达。
Cancer Chemother Pharmacol. 1994;34(1):81-5. doi: 10.1007/BF00686118.
2
Benzamide potentiation of the cytotoxicity of bifunctional galactitol [correction of galacticol] in resistant P388 leukemia correlates with inhibition of DNA ligase II.苯甲酰胺增强双功能半乳糖醇（纠正：半乳糖醇）对耐药P388白血病细胞的细胞毒性作用与DNA连接酶II的抑制相关。
Cancer Chemother Pharmacol. 1992;30(4):325-9. doi: 10.1007/BF00686304.

本文引用的文献

1
Alkylation by 1,2:5,6-dianhydrogalactitol of deoxyribonucleic acid and guanosine.1,2:5,6-二脱水半乳糖醇对脱氧核糖核酸和鸟苷的烷基化作用。
Biochem J. 1980 Mar 1;185(3):659-66. doi: 10.1042/bj1850659.
2
Drug resistance studies on intraspecific hybridomas.
Arch Geschwulstforsch. 1981;51(1):119-24.
3
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.通过维拉帕米增强长春新碱和长春碱的细胞毒性在体内和体外克服P388白血病对长春新碱的耐药性
Cancer Res. 1981 May;41(5):1967-72.
4
Inheritance of cellular resistance to the antitumor agent ICRF 159 in somatic cell hybrids.体细胞杂种中细胞对抗肿瘤剂ICRF 159抗性的遗传。
J Natl Cancer Inst. 1982 Jun;68(6):977-80.
5
Cross-resistance of cultured murine leukemia vincristine-resistant P388 cells to vinblastine, vindesine, and bis (N-ethylidene vindesine) disulfide, disulfate.培养的小鼠白血病长春新碱耐药P388细胞对长春花碱、长春地辛和双（N-亚乙基长春地辛）二硫化物二硫酸盐的交叉耐药性。
J Natl Cancer Inst. 1982 Jun;68(6):1023-6.
6
Clinical trials with the hexitol derivatives in the U.S.美国针对己糖醇衍生物开展的临床试验
Cancer. 1981 Feb 1;47(3):442-51. doi: 10.1002/1097-0142(19810201)47:3<442::aid-cncr2820470304>3.0.co;2-1.
7
Effects of some sugar alcohol derivatives on mutation and induction of sister chromatid exchanges.某些糖醇衍生物对突变及姐妹染色单体交换诱导的影响。
Cancer Res. 1983 Oct;43(10):4530-6.
8
Drug resistance in cancer.癌症中的耐药性。
Cancer Treat Rep. 1984 Jan;68(1):87-99.
9
Effect of antitumour agents: Degranol, Mannitol-myleran, Dibromomannitol and Dibromodulcitol on cell morphology in tissue cultures.
Neoplasma. 1967;14(2):159-66.
10
1,6-Dibromo-1,6-dideoxy-dulcitol: a new antitumoral agent.1,6-二溴-1,6-二脱氧卫矛醇：一种新型抗肿瘤药物。
Nature. 1967 Jan 28;213(5074):402-3. doi: 10.1038/213402a0.