流感病毒的温度敏感突变体。十六。将乌东/72-ts-1A2供体病毒中存在的两个温度敏感损伤转移至维多利亚/3/75野生型病毒。 - Suppr

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Temperature-sensitive mutants of influenza virus. XVI. Transfer of the two ts lesions present in the Udorn/72-ts-1A2 donor virus to the Victoria/3/75 wild-type virus.

作者信息

Murphy B R, Wood F T, Massicot J G, Chanock R M

出版信息

Virology. 1978 Jul 15;88(2):244-51. doi: 10.1016/0042-6822(78)90281-7.

DOI:10.1016/0042-6822(78)90281-7

PMID:695327

Abstract

摘要

相似文献

Temperature-sensitive mutants of influenza virus. XVI. Transfer of the two ts lesions present in the Udorn/72-ts-1A2 donor virus to the Victoria/3/75 wild-type virus.流感病毒的温度敏感突变体。十六。将乌东/72-ts-1A2供体病毒中存在的两个温度敏感损伤转移至维多利亚/3/75野生型病毒。

Virology. 1978 Jul 15;88(2):244-51. doi: 10.1016/0042-6822(78)90281-7.

Temperature-sensitive mutants of influenza virus. XV. The genetic and biological characterization of a recombinant influenza virus containing two ts lesions produced by mating two complementing, single lesion ts mutants.流感病毒的温度敏感突变体。十五、一种重组流感病毒的遗传和生物学特性，该重组病毒含有通过将两个互补的单损伤温度敏感突变体杂交产生的两个温度敏感损伤。

Virology. 1978 Jul 15;88(2):231-43. doi: 10.1016/0042-6822(78)90280-5.

Temperature-sensitive mutants of influenza A virus: transfer of the two temperature-sensitive lesions in the Udorn/72-ts-1A2 virus to the A2Hong Kong/123/77 (H1N1) wild-type virus.甲型流感病毒的温度敏感突变体：将乌东/72-ts-1A2病毒中的两个温度敏感损伤转移至A2香港/123/77（H1N1）野生型病毒。

Infect Immun. 1980 Jun;28(3):792-8. doi: 10.1128/iai.28.3.792-798.1980.

Temperature-sensitive mutants of influenza A virus. Transfer of the two ts-1A2 ts lesions present in the Udorn/72-ts-1A2 donor virus to the influenza A/Alaska/6/77 (H3N2) wild type virus.甲型流感病毒的温度敏感突变体。将存在于乌栋/72-ts-1A2供体病毒中的两个ts-1A2 ts损伤转移至甲型流感病毒/阿拉斯加/6/77（H3N2）野生型病毒。

Arch Virol. 1980;65(2):175-86. doi: 10.1007/BF01317329.

Production and level of genetic stability of an influenza A virus temperature-sensitive mutant containing two genes with ts mutations.一种含有两个带有温度敏感（ts）突变基因的甲型流感病毒温度敏感突变株的产生及其遗传稳定性水平

Infect Immun. 1982 Jul;37(1):235-42. doi: 10.1128/iai.37.1.235-242.1982.

Temperature-sensitive mutants of influenza virus. Identification of the loci of the two ts lesions in the Udorn-ts-1A2 donor virus and the correlation of the presence of these two ts lesions with a predictable level of attenuation.流感病毒的温度敏感突变体。乌栋ts-1A2供体病毒中两个温度敏感损伤位点的鉴定以及这两个温度敏感损伤的存在与可预测的减毒水平的相关性。

Virology. 1980 Feb;101(1):242-9. doi: 10.1016/0042-6822(80)90499-7.

Temperature sensitive mutants of influenza virus. IX. Genetic and biological characterization of TS-1[E] lesions when transferred to a 1972 (H3N2) influenza A virus.流感病毒的温度敏感突变体。IX. 当TS-1[E]损伤转移至1972年甲型（H3N2）流感病毒时的遗传学和生物学特征

Virology. 1975 Aug;66(2):551-62. doi: 10.1016/0042-6822(75)90227-5.

Evaluation of a phenotypic revertant of the A/Alaska/77-ts-1A2 reassortant virus in hamsters and in seronegative adult volunteers: further evidence that the temperature-sensitive phenotype is responsible for attenuation of ts-1A2 reassortant viruses.对A/阿拉斯加/77-ts-1A2重配病毒在仓鼠和血清阴性成年志愿者中的表型回复突变体的评估：温度敏感表型导致ts-1A2重配病毒减毒的进一步证据。

Infect Immun. 1982 May;36(2):645-50. doi: 10.1128/iai.36.2.645-650.1982.

Temperature-sensitive mutants of influenza A virus. XI. Transfer of ts lesions in the Hong Kong/68-ts-1 [a] virus to the influenza A/Udorn/72 wild type.甲型流感病毒的温度敏感突变体。十一。香港/68-ts-1 [a]病毒中温度敏感损伤向甲型流感病毒/乌东/72野生型的转移。

J Infect Dis. 1976 Dec;134(6):577-84. doi: 10.1093/infdis/134.6.577.

Temperature-sensitive mutants of influenza A virus: evaluation of the A/Victoria/75-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers.甲型流感病毒温度敏感突变体：血清阴性成年志愿者中A/维多利亚/75-ts-1A2温度敏感重组病毒的评估

Infect Immun. 1979 Feb;23(2):249-52. doi: 10.1128/iai.23.2.249-252.1979.

引用本文的文献

Wild-type and attenuated influenza virus infection of the neonatal rat brain.新生大鼠脑的野生型和减毒流感病毒感染

J Neurovirol. 2004 Oct;10(5):305-14. doi: 10.1080/13550280490499579.

Sequential addition of temperature-sensitive missense mutations into the PB2 gene of influenza A transfectant viruses can effect an increase in temperature sensitivity and attenuation and permits the rational design of a genetically engineered live influenza A virus vaccine.将温度敏感型错义突变依次添加到甲型流感转染病毒的PB2基因中，可提高温度敏感性并实现减毒，从而有助于合理设计基因工程甲型流感活病毒疫苗。

J Virol. 1995 Oct;69(10):5969-77. doi: 10.1128/JVI.69.10.5969-5977.1995.

Growth of influenza A viruses in hamsters.甲型流感病毒在仓鼠体内的生长情况。

Arch Virol. 1980;65(2):99-107. doi: 10.1007/BF01317321.

Arch Virol. 1980;65(2):175-86. doi: 10.1007/BF01317329.

Temperature-sensitive mutants of influenza A virus: evaluation of the Alaska/77-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers.甲型流感病毒温度敏感突变体：血清阴性成年志愿者中阿拉斯加/77-ts-1A2温度敏感重组病毒的评估

Arch Virol. 1980;65(2):169-73. doi: 10.1007/BF01317328.

Infect Immun. 1980 Jun;28(3):792-8. doi: 10.1128/iai.28.3.792-798.1980.

Evaluation of influenza A/Hong Kong/123/77 (H1N1) ts-1A2 and cold-adapted recombinant viruses in seronegative adult volunteers.甲型流感病毒/香港/123/77（H1N1）ts-1A2及冷适应重组病毒在血清阴性成年志愿者中的评估。

Infect Immun. 1980 Aug;29(2):348-55. doi: 10.1128/iai.29.2.348-355.1980.

Live influenza A/Victoria/75 (H3N2) virus vaccines: reactogenicity, immunogenicity, and protection against wild-type virus challenge.甲型流感病毒/维多利亚/75（H3N2）活病毒疫苗：反应原性、免疫原性及对野生型病毒攻击的防护作用

Infect Immun. 1982 Oct;38(1):141-6. doi: 10.1128/iai.38.1.141-146.1982.

Infect Immun. 1982 Jul;37(1):235-42. doi: 10.1128/iai.37.1.235-242.1982.

Infect Immun. 1982 May;36(2):645-50. doi: 10.1128/iai.36.2.645-650.1982.

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