Fujii T
Electroencephalogr Clin Neurophysiol. 1977 Aug;43(2):238-47. doi: 10.1016/0013-4694(77)90131-6.
Electric activities from brain slices of guinea pig olfactory cortex were studied during gradual cooling without a temperature gradient. At normal temperature the potential evoked by stimulation of the lateral olfactory tract consists of an initial spike (IS), a negative (N), and a positive (P) potentials. The IS potential has been considered to be presynaptic in origin and the latter two postsynaptic. During cooling from 37 to 15 degrees C, the amplitude of both the IS and the N potentials increased to attain the maximum value (10-36% increase) at about 32 degrees C, then decreased gradually and disappeared at around 15 degrees C. On the other hand, the durations of the IS and the N potentials were prolonged gradually on cooling from 37 to 17 degrees C. Most of the olfactory cortical neurons responded with one or two firings to the tract stimulation. The firing numbers increased on cooling down to about 32 degrees C and declined on further cooling, which corresponds with the behavior of the N potential. All these effects were reversible on rewarming. Augmentation of the N potential might depend primarily on the increase in amplitude of the IS potential and secondarily on the increase of amount of liberated transmitter substance and/or the delayed inactivation process of the transmitter action.
在无温度梯度的逐渐冷却过程中，对豚鼠嗅皮质脑片的电活动进行了研究。在常温下，刺激外侧嗅束诱发的电位由一个起始锋电位（IS）、一个负电位（N）和一个正电位（P）组成。IS电位被认为起源于突触前，而后两者起源于突触后。在从37℃冷却至15℃的过程中，IS和N电位的幅度均增大，在约32℃时达到最大值（增加10 - 36%），然后逐渐减小并在约15℃时消失。另一方面，从37℃冷却至17℃时，IS和N电位的持续时间逐渐延长。大多数嗅皮质神经元对束刺激以一次或两次放电做出反应。放电次数在冷却至约32℃时增加，进一步冷却时减少，这与N电位的变化情况相符。所有这些效应在复温时均可逆转。N电位的增强可能主要取决于IS电位幅度的增加，其次取决于释放的递质物质数量的增加和/或递质作用的延迟失活过程。
