Davies D S
Eur J Respir Dis Suppl. 1982;119:67-72.
In the past decade there have been a number of studies of the pharmacokinetics and metabolism of drugs used in the treatment of asthma. The influence of route of administration on metabolism was first noted in studies with isoprenaline and then extended to other adrenaline-like beta-adrenoceptor agonists including isoetharine, terbutaline and salbutamol. Later studies with disodium cromoglycate and recent studies on glucocorticoids such as beclomethasone and budesonide have confirmed the importance of route of administration in the kinetics and metabolism of anti-asthmatic drugs. Thus, although there are differences in routes of metabolism, the selectivity of action within the airways when the drugs are inhaled is to a large part dependent on pharmacokinetic and metabolic factors.
在过去十年里，已经有多项关于治疗哮喘所用药物的药代动力学和代谢的研究。给药途径对代谢的影响最初是在对异丙肾上腺素的研究中被发现的，随后扩展到其他肾上腺素样β-肾上腺素能受体激动剂，包括异他林、特布他林和沙丁胺醇。后来对色甘酸钠的研究以及最近对倍氯米松和布地奈德等糖皮质激素的研究证实了给药途径在抗哮喘药物的动力学和代谢中的重要性。因此，尽管代谢途径存在差异，但药物吸入时在气道内的作用选择性在很大程度上取决于药代动力学和代谢因素。
