一个超级基因家族的等位基因和非等位基因同源性。
Allelic and nonallelic homology of a supergene family.
作者信息
Ohta T
出版信息
Proc Natl Acad Sci U S A. 1982 May;79(10):3251-4. doi: 10.1073/pnas.79.10.3251.
Abstract
A model to explain the high degree of polymorphism at the major histocompatibility complex (MHC) is described. The model incorporates domain transfer between the different loci in a supergene family by either gene conversion or double unequal crossing-over. Population genetics theory is used to formulate changes in the probabilities of allelic and nonallelic gene identities and equilibrium values are obtained. The observed degree of allelic and nonallelic homology in the complex can be explained by assuming that a domain is converted at a rate of 10(-5) to 10(-6) per generation and reasonable values of other parameters. This rate of domain transfer is compatible with the observed high mutation rate at marker loci in the major histocompatibility complex.
摘要
本文描述了一个用以解释主要组织相容性复合体（MHC）高度多态性的模型。该模型通过基因转换或双不等交换，纳入了超基因家族中不同基因座之间的结构域转移。运用群体遗传学理论来阐述等位基因和非等位基因同一性概率的变化，并得出平衡值。通过假设每个世代结构域以10^(-5)至10^(-6)的速率发生转换以及其他参数的合理取值，复合体中等位基因和非等位基因同源性的观察程度得以解释。这种结构域转移速率与主要组织相容性复合体中标记基因座观察到的高突变率相符。
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