人类白细胞抗原与多发性硬化症的异质性
HLA and heterogeneity of multiple sclerosis.
作者信息
Engell T, Raun N E, Thomsen M, Platz P
出版信息
Neurology. 1982 Sep;32(9):1043-6. doi: 10.1212/wnl.32.9.1043.
PMID:6955632
Abstract
Age at onset, debut symptoms, optic nerve signs, and severity of symptoms were evaluated from the medical records of 135 patients with MS. HLA-D/DR2 was significantly more frequent in rapidly progressive MS, and D/DR2 seemed to confer both susceptibility to the disease and to more rapid progression. However, D/DR3 seemed to protect against rapid progression.
摘要
从135例多发性硬化症（MS）患者的病历中评估发病年龄、首发症状、视神经体征和症状严重程度。HLA-D/DR2在快速进展型MS中显著更常见，且D/DR2似乎赋予了对该疾病的易感性以及更快的进展。然而，D/DR3似乎可预防快速进展。
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