Runmarker B, Martinsson T, Wahlström J, Andersen O
Department of Neurology, Sahlgren's Hospital, Göteborg, Sweden.
J Neurol. 1994 May;241(6):385-90. doi: 10.1007/BF02033356.
The patients of a multiple sclerosis (MS) incidence cohort with 25 years of longitudinal follow-up were typed for HLA-DR and DQ. This type of cohort provides reliable data for gene frequencies and prognostic studies. The influence of sampling bias, mainly due to mortality during the long follow-up, was accounted for. A positive association between MS and DR15,DQ6 was confirmed, but this haplotype did not influence prognosis. There was no difference in haplotype frequency between relapsing-remitting and primary chronic progressive MS. DR17,DQ2 was significantly over-represented in the quartile with the most malignant course. The haplotype DR1,DQ5, which was found rather less frequently in MS patients, also tended to be associated with a poorer prognosis.
对一个进行了25年纵向随访的多发性硬化症（MS）发病队列的患者进行了HLA - DR和DQ分型。这种队列可为基因频率和预后研究提供可靠数据。考虑到了主要由长期随访期间的死亡率导致的抽样偏差的影响。证实了MS与DR15、DQ6之间存在正相关，但这种单倍型不影响预后。复发缓解型MS和原发性慢性进展型MS之间的单倍型频率没有差异。DR17、DQ2在病程最恶性的四分位数中显著过度代表。在MS患者中发现频率相对较低的单倍型DR1、DQ5也倾向于与较差的预后相关。
