前列腺素D2对大鼠心血管及体温的中枢性影响

Central cardiovascular and thermal effects of prostaglandin D2 in rats.

作者信息

Sirén A L

出版信息

Prostaglandins Leukot Med. 1982 Apr;8(4):349-59. doi: 10.1016/0262-1746(82)90058-0.

Abstract

Prostaglandin D2 (PGD2) is the most common prostaglandin type of the rat brain. Recently a neuromodulator role for PGD2 has been suggested. In the present work the central cardiovascular and thermal effects of PGD2 were studied in urethane-anaesthetised rats. When administered at the doses of 0.001-10 micrograms/rat into the lateral cerebral ventricle (i.c.v.), PGD2 slightly increased the blood pressure, heart rate and body temperature. The highest dose caused also an initial hypotensive effect. Upon intravenous injections PGD2 (0.1-10 micrograms/rat) initially decreased and then weakly increased the blood pressure but had only negligible effects on heart rate and body temperature. Central pretreatment with sodium meclofenamate or indomethacin (1 mg/rat i.c.v.) antagonised effectively all the recorded central effects of PGD2. The central cardiovascular and thermal effects of PGD2 were much weaker than those obtained earlier with other prostaglandins, such as PGF2 alpha and PGE2. Therefore, in spite of its abundance in the brain PGD2 may not be very important for the central cardiovascular and thermal regulation in the rat.

摘要

前列腺素D2（PGD2）是大鼠脑中最常见的前列腺素类型。最近有人提出PGD2具有神经调节作用。在本研究中，我们在乌拉坦麻醉的大鼠中研究了PGD2对中枢心血管和体温的影响。当以0.001 - 10微克/大鼠的剂量注入侧脑室（脑室内）时，PGD2会轻微升高血压、心率和体温。最高剂量还会引起初始的降压作用。静脉注射PGD2（0.1 - 10微克/大鼠）时，血压最初下降，然后微弱升高，但对心率和体温的影响可忽略不计。用甲氯芬那酸钠或吲哚美辛（1毫克/大鼠脑室内注射）进行中枢预处理可有效拮抗PGD2记录到的所有中枢效应。PGD2对中枢心血管和体温的影响比早期用其他前列腺素如PGF2α和PGE2所获得的影响要弱得多。因此，尽管PGD2在脑中含量丰富，但它可能对大鼠中枢心血管和体温调节不是非常重要。