Woodruff R, Roberts M
Aust N Z J Med. 1978 Aug;8(4):439-44. doi: 10.1111/j.1445-5994.1978.tb04921.x.
A proportion of patients with blast crisis of CML have blast cells identical to those found in common non-T, non-B all, and whilst this disease is often referred to as lymphoid blast crisis (LBC), evidence is presented that it may in fact arise from a prelymphoid, pre-myeloid (pluripotential) stem cell. Recently developed membrane and enzyme markers (anti-ALL antiserum, TdT assay) have provided convenient diagnostic tests for the detection of LBC. The clinical and haematological features of LBC are reviewed: patients with LBC show a higher response rate to therapy with vincristine and prednisolone, and their survival may be significantly prolonged. The frequent occurrence of meningeal leukaemia suggests the need for prophylactic CNS therapy in LBC patients achieving remission.
一部分慢性粒细胞白血病急变期患者的原始细胞与常见的非T、非B急性淋巴细胞白血病中的原始细胞相同，虽然这种疾病常被称为淋巴细胞性急变期（LBC），但有证据表明它实际上可能起源于前淋巴细胞、前髓细胞（多能）干细胞。最近开发的膜和酶标志物（抗ALL抗血清、末端脱氧核苷酸转移酶检测）为LBC的检测提供了便捷的诊断试验。本文综述了LBC的临床和血液学特征：LBC患者对长春新碱和泼尼松龙治疗的反应率较高，其生存期可能显著延长。脑膜白血病的频繁发生提示对达到缓解的LBC患者需要进行预防性中枢神经系统治疗。
