Olive M, Ruch J V
Arch Oral Biol. 1982;27(6):505-11. doi: 10.1016/0003-9969(82)90092-9.
Diazo-oxo-norleucine (DON), an analogue of glutamine, prevented odontoblast differentiation in cultured tooth germs. Diazo-oxo-norleucine added after the onset of odontoblast differentiation, did not affect the secretion of predentine or the functional differentiation of ameloblasts. DON decreased explant volume and modified cell kinetics, decreasing mitotic index, labelling index and number of grains per nucleus; the 5 phase of the cell cycle was lengthened. These modifications of cell kinetics should be considered when interpreting the effects of DON on odontoblast differentiation.
重氮氧代正亮氨酸（DON）是谷氨酰胺的类似物，可阻止培养的牙胚中牙本质细胞的分化。在牙本质细胞分化开始后添加重氮氧代正亮氨酸，并不影响前期牙本质的分泌或成釉细胞的功能分化。DON减小了外植体体积并改变了细胞动力学，降低了有丝分裂指数、标记指数和每个细胞核的颗粒数；细胞周期的G5期延长。在解释DON对牙本质细胞分化的影响时，应考虑细胞动力学的这些改变。
