Kunz C, Hofmann H, Carda K
Wien Klin Wochenschr. 1978 Oct 13;90(19):707-10.
A field study was performed on 118 members of army personnel with the intranasally-applied live influenza vaccine, RIT 4050. 91 subjects were revaccinated 7 days thereafter. The immune response was best in subjects with a low prevaccination titre and was better in subjects vaccinated twice than only once. An immune response was also detected in the nasal secretion measuring the secretory IgA antibodies. Live influenza vaccine can be regarded as a suitable alternative to other influenza vaccines, with the qualification that it lacks an influenza B component.
对118名军队人员进行了一项关于鼻内接种减毒活流感疫苗RIT 4050的现场研究。7天后，91名受试者再次接种疫苗。免疫反应在接种前滴度较低的受试者中最佳，接种两次的受试者比仅接种一次的受试者免疫反应更好。在测量分泌型IgA抗体的鼻分泌物中也检测到了免疫反应。减毒活流感疫苗可被视为其他流感疫苗的合适替代品，但它缺乏乙型流感成分。
