Frazee W J, Mallek H M, Nakamoto T
Arch Oral Biol. 1982;27(7):561-5. doi: 10.1016/0003-9969(82)90070-x.
Timed-pregnant rats were injected with a total of 90 microgram of retinoic acid from day 13 until delivery. Other pregnant groups were given either a total of 390 microgram of retinol from day 5 or a total of 270 microgram of retinol from day 13 until delivery. Although the weight gains and food intake of the dams during gestation showed no difference between groups, the long bones were slightly heavier in pups born from retinoic acid-injected dams. Total collagen content in both mandibles and long bones did not show differences between retinoic acid- and retinol-injected groups, but collagen synthesis in both bones was greatly increased in the retinoic acid-injected groups. Calcium content of the mandible in the retinol-injected group from day 13 of gestation was increased, whereas 45Ca uptake of long bone of this group was increased. Retinoic acid, when injected in physiological doses during gestation, may have some effects on the organic phase of bone, long bones being slightly more sensitive to retinoic acid than the mandibles.
从妊娠第13天到分娩，给处于妊娠特定时期的大鼠注射总共90微克视黄酸。其他妊娠组大鼠则从第5天开始共给予390微克视黄醇，或从第13天到分娩共给予270微克视黄醇。尽管妊娠期间母鼠的体重增加和食物摄入量在各组之间没有差异，但注射视黄酸的母鼠所生幼崽的长骨略重。注射视黄酸组和注射视黄醇组的下颌骨和长骨中的总胶原蛋白含量没有差异，但注射视黄酸组的两种骨骼中的胶原蛋白合成均大幅增加。从妊娠第13天起，注射视黄醇组的下颌骨钙含量增加，而该组的长骨对45Ca的摄取增加。在妊娠期间注射生理剂量的视黄酸，可能会对骨骼的有机相产生一些影响，长骨对视黄酸的敏感性略高于下颌骨。
