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6-硫鸟嘌呤作为肝毒性静脉闭塞性疾病的病因

6-thioguanine as a cause of toxic veno-occlusive disease of the liver.

作者信息

Satti M B, Weinbren K, Gordon-Smith E C

出版信息

J Clin Pathol. 1982 Oct;35(10):1086-91. doi: 10.1136/jcp.35.10.1086.

DOI:10.1136/jcp.35.10.1086
PMID:6957419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC497888/
Abstract

Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinoside in the second patient.

摘要

在一名慢性粒细胞白血病患者的针吸活检标本中以及另一名急性髓细胞白血病患者尸检的肝脏中发现了肝静脉闭塞性疾病病变。治疗包括给予6-硫鸟嘌呤,这是第一名患者使用的唯一相关化合物,在第二名患者中则与阿糖胞苷联合使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/e2f528db757e/jclinpath00503-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/05414ae1817d/jclinpath00503-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/061eefe524ac/jclinpath00503-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/b6b20d2458d8/jclinpath00503-0048-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/6e44b6a442cc/jclinpath00503-0048-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/d8b8c9fb1516/jclinpath00503-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/9365a96d45e7/jclinpath00503-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/e2f528db757e/jclinpath00503-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/05414ae1817d/jclinpath00503-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/061eefe524ac/jclinpath00503-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/b6b20d2458d8/jclinpath00503-0048-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/6e44b6a442cc/jclinpath00503-0048-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/d8b8c9fb1516/jclinpath00503-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/9365a96d45e7/jclinpath00503-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/497888/e2f528db757e/jclinpath00503-0050-b.jpg

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本文引用的文献

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Liver damage after prolonged urethane therapy.长期氨基甲酸乙酯治疗后的肝损伤。
Am J Clin Pathol. 1952 Jan;22(1):22-7. doi: 10.1093/ajcp/22.1.22.
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Therapeutic trials in childhood ALL: what's their future?儿童急性淋巴细胞白血病的治疗试验:其未来走向如何?
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Peliosis hepatis induced by 6-thioguanine administration.6-硫鸟嘌呤给药诱导的肝紫癜
Gut. 1988 Sep;29(9):1265-9. doi: 10.1136/gut.29.9.1265.
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The human liver after radiation injury. A form of veno-occlusive disease.辐射损伤后的人体肝脏。一种肝静脉闭塞病形式。
Am J Pathol. 1966 Apr;48(4):597-611.
5
Jaundice after treatment of leukemia with busulphan.白消安治疗白血病后出现的黄疸。
Br Med J. 1971 Mar 6;1(5748):556-7. doi: 10.1136/bmj.1.5748.556-b.
6
Granulomatous hepatitis in a patient receiving allopurinol.一名接受别嘌醇治疗的患者出现肉芽肿性肝炎。
Gastroenterology. 1972 Jan;62(1):101-4.
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Human radiation hepatitis. A morphologic study with emphasis on the late changes.人类放射性肝炎。一项侧重于晚期变化的形态学研究。
Arch Pathol. 1973 Jul;96(1):21-6.
8
Disposition of arabinosylcytosine (NSC-63878) and 6-THIOGUANINE (NSC-752) in solid L1210 leukemia tumor-bearing mice.阿糖胞苷(NSC - 63878)和6 - 硫鸟嘌呤(NSC - 752)在携带实体L1210白血病肿瘤小鼠体内的处置情况。
Cancer Chemother Rep. 1973 Sep-Oct;57(3):275-89.
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