Gill R A, Onstad G R, Cardamone J M, Maneval D C, Sumner H W
Ann Intern Med. 1982 Jan;96(1):58-60. doi: 10.7326/0003-4819-96-1-58.
Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented a unique opportunity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the first case of veno-occlusive related solely to 6-thioguanine.
一名23岁急性淋巴细胞白血病男性在接受6-硫鸟嘌呤维持治疗10个月后发生了临床上可逆转的肝静脉闭塞性疾病。系列肝脏活检显示了强烈的窦性充血的发展和消退。尽管这种疾病在临床上是可逆的，但终末肝静脉周围仍存在一些内膜下纤维化。该病例提供了一个独特的机会来观察临床上可逆转的肝静脉闭塞性疾病随时间的组织学特征，并且可能是首例仅与6-硫鸟嘌呤相关的静脉闭塞病例。
